Research field

Myosin Motors

 
1. Cell Migration Mechanism
  1. Investigation of motor protein structural dynamics during cellular movement
  2. Analysis of conformational changes in myosin molecules from different species 
  3. High-resolution structural studies using electron microscopy
2. Cytoskeletal Organization
  1. Study of intracellular actin filament rearrangement through actin-myosin interactions
  2. Comparative analysis of myosin motor domains from different organisms
  3. Investigation of force generation mechanisms in molecular motors
3. Regulatory Protein Dynamics
  1. Examination of activation-inactivation structural changes in regulatory proteins
  2. Study of conformational states using advanced imaging techniques
  3. Analysis of protein-protein interactions in motor complexes
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Development of Electron Microscopy based Molecular Imaging Analysis

 
1. Advanced Cryo-EM Methodology
  1. Development of high-resolution tertiary structural analysis using Cryo-EM imaging
  2. Optimization of sample preparation and grid preparation techniques
  3. Implementation of state-of-the-art image processing workflows
2. Technical Development
  1. Innovation in sample preparation methods for electron microscopy applications
  2. Design and optimization of Cryo-EM grid setup protocols
  3. Enhancement of negative staining techniques for preliminary analysis
3. Integrated Imaging Approaches
  1. Development of integrative methods for high-resolution biological specimen imaging
  2. Combination of multiple imaging modalities for comprehensive structural analysis
  3. Advanced data processing and 3D reconstruction techniques